A bit late to this, as usual, but as it’s now November 2019, it seems like as good a time as any to mention that Blade Runner is now supported by ScummVM.
Until recently, the game was technically playable on 64-bit Windows, and I personally found the jiggery-pokery here sufficient to get things up and running on my own machine, although that doesn’t seem to have been the case for everyone, and some have claimed that playing on a modern PC messes up one or two timing-specific puzzles later on in the game.
I haven’t played Blade Runner all the way through for a long time, although it’s a game I think about often. It was the first review I submitted to FFG and, some years later, I wrote about how it was one of the first games that left a significant mark on me. That piece involved playing through some of the early stages again and I was sorely tempted to keep going.
I didn’t, though, so I can’t comment on any gameplay issues the workaround may or may not cause. I understand that playing through ScummVM is a safer bet in this regard, although again I can’t vouch for that myself. There’s also an option to experience an alternative version of the game featuring some restored content that the ScummVM team unearthed during the (long) quest to get it working, and I’ll be interested to try that out.
The main thing you need, of course, is a copy of the game, which isn’t that easy to get hold of legally unless, like me, you still have your original discs. An official re-release via GOG or some other platform is unlikely due to fairly complex rights issues, but I dare say you’d be able to find it on some abandonware site or other.
Even if it’s a flawed game, it’s also an interesting one, and I’m personally glad more people will be hopefully now be able to experience it. Thanks, brainy internet boffins!
[Edit: As befits someone with their finger on the pulse of modern and retro gaming news, I was of course completely wrong about the lack of a re-release, and shortly before Christmas, GOG.com added the game to their library. Huzzah!]